Post-Doctoral Associate in Hydrogen/Deuterium Exchange Mass Spectrometry and Proteomics
The proteomics group at the Broad Institute of MIT and Harvard is a widely recognized leader in the field of biological mass spectrometry and proteomics. We are looking for a highly motivated post-doctoral associate to work on cutting-edge hydrogen/deuterium exchange-mass spectrometry (HDX-MS) technology development projects. The position will offer many opportunities to work on collaborative projects focused on cancer biology, epigenetics, and chemical biology, with a wide range of Broad, MIT, Harvard and Harvard hospital-affiliated scientists. Working in our group provides the potential for your contributions to be utilized and recognized across a global network of researchers in mass spectrometry-based proteomics and HDX-MS.
The specific research areas of immediate interest are:
- implement HDX-MS methods for the analysis of protein-protein and protein-ligand interactions, using state-of-the-art LEAP automation
- develop and implement methods for the analysis of membrane proteins and their complexes by automated, on-line lipid filtration and other approaches available on the LEAP autosampler
- develop and optimize HDX-MS methods for the analysis of proteome-level samples using subzero chromatography, the latest addition in the HDX-MS arsenal
Qualifications:
- A Ph.D. in analytical chemistry, chemical biology, biochemistry or a closely related field
- excellent scientific productivity, evidenced by high-quality research publications in peer reviewed journals
- track record of conducting independent and creative research
- excellent verbal and written communication skills
- exceptional organizational skills, critical thinking skills and attention to detail.
Hands on skills and knowledge in one or more of the following areas will be considered an advantage:
- HDX-MS sample preparation, data generation, analysis and interpretation
- state-of-the-art mass spectrometry-based proteomics, cross-linking or FPOP
- experience with LEAP or any other liquid handling automation platform
- demonstrated programming skills in either R or Python
- expertise in computational analysis of large-scale datasets
The Broad Institute is a world-leading non-profit research organization dedicated to realizing the promise of the post-genomic era for human benefit. Located in Cambridge, MA with strong ties to MIT, Harvard, and world class Boston hospitals, the Broad Institute brings together scientists of diverse backgrounds to solve critical problems in biology and medicine in an interdisciplinary manner. The Broad Institute, and the embedded proteomics group (www.broadinstitute.org/proteomics), have an outstanding track-record in training the next generation of research scientists and in developing and applying proteomic technologies critical to address important questions in biology and medicine. We collaborate with top-level researchers throughout the world, and results of these studies and our technology developments are published in top-tier journals. The successful candidate should have both the ability and desire to function in such an open, interdisciplinary, and highly collaborative environment.
Interested scientists are encouraged to apply online at the Broad Website (req 2487). Informal queries can be addressed to Steve Carr, Director of Proteomics, Broad Institute and Malvina Papanastasiou, Senior Research Scientist at jobs-proteomics@broadinstitute.org.